HEALTHY AGING – University of California at Berkeley Clinical Study

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University of California at Berkeley Clinical Study

Healthy AgingA randomized, double blind, placebo-controlled human clinical study was performed at the University of California, Berkeley and the University of Arkansas for Medical Sciences to evaluate the impact of Fortetropin supplementation on the rate of muscle protein synthesis in 20 healthy, older men and women (66.4 ± 4.5 yr) using a 2H2O labeling methodology and mass spectrometry analysis of muscle microbiopsy samples.  Subjects were given either Fortetropin or macronutrient matched placebo for 21 days prior to undergoing a muscle microbiopsy.  The key findings of this study were:

  • The average fractional synthesis for a majority of muscle proteins was higher in the Fortetropin group compared to placebo group (p<0.0001).
  • The overall magnitude of increase was 15% in the Fortetropin group, demonstrating a stimulatory effect on the rate of muscle protein synthesis.  

Reference:

Evans W, Shankaran M, Nyangau E, Field T, Mohammed H, Wolfe R, Hellerstein M.  Effects of Fortetropin® on the rate of muscle protein synthesis in older men and women: a randomized, double-blinded control study.  Manuscript in preparation.